Cargando…

Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer

BACKGROUND: High EREG and AREG expression, and left-sided primary tumours are associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (CRC), but a unifying explanation of these findings is lacking. METHODS: RNA-seq, gene expression ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Michael S, McGuffey, Elizabeth J, Morris, Jeffrey S, Manyam, Ganiraju, Baladandayuthapani, Veerabahdran, Wei, Wei, Morris, Van K, Overman, Michael J, Maru, Dipen M, Jiang, Zhi-Qin, Hamilton, Stanley R, Kopetz, Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984478/ https://www.ncbi.nlm.nih.gov/pubmed/27272216 http://dx.doi.org/10.1038/bjc.2016.87

Ejemplares similares

Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine
por: Overman, M J, et al.
Publicado: (2010)

MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea
por: McDaid, J R, et al.
Publicado: (2009)

Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients
por: Wadhwa, Roopma, et al.
Publicado: (2017)

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
por: van Nifterik, K A, et al.
Publicado: (2010)

MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
por: Hassel, J C, et al.
Publicado: (2010)

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance
por: Ganapathi, S K, et al.
Publicado: (2014)

Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
por: Steele, N, et al.
Publicado: (2009)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6
por: Sorokin, Alexey V., et al.
Publicado: (2022)

E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
por: Lombaerts, M, et al.
Publicado: (2006)

Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer
por: Cheng, Y Y, et al.
Publicado: (2007)

The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients
por: Van der Auwera, I, et al.
Publicado: (2009)

Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer
por: Yokoi, K, et al.
Publicado: (2017)

Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study
por: Phelps, David L, et al.
Publicado: (2017)

Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells
por: Martín, V, et al.
Publicado: (2013)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer
por: Advani, Shailesh Mahesh, et al.
Publicado: (2019)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3
por: Patel, S A A, et al.
Publicado: (2014)

Bayesian methods for expression-based integration of various types of genomics data
por: Jennings, Elizabeth M, et al.
Publicado: (2013)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination
por: Cannistraro, Vincent J., et al.
Publicado: (2010)

Role of DNA methylation and the DNA methyltransferases in learning and memory
por: Morris, Michael J., et al.
Publicado: (2014)

Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR
por: Gebhard, Claudia, et al.
Publicado: (2006)

MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon
por: Raghav, Kanwal, et al.
Publicado: (2016)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray
por: Huntriss, John, et al.
Publicado: (2015)

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
por: Dai, Wei, et al.
Publicado: (2008)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

iBAG: integrative Bayesian analysis of high-dimensional multiplatform genomics data
por: Wang, Wenting, et al.
Publicado: (2013)

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern
por: Bellizzi, Dina, et al.
Publicado: (2013)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
por: Goldsmith, Chloe, et al.
Publicado: (2021)

Genomics of CpG Methylation in Developing and Developed Zebrafish
por: McGaughey, David M., et al.
Publicado: (2014)

CpG Distribution and Methylation Pattern in Porcine Parvovirus
por: Tóth, Renáta, et al.
Publicado: (2013)

CpG methylation patterns of human mitochondrial DNA
por: Liu, Baojing, et al.
Publicado: (2016)

Different Methylation of CpG-SNPs in Behcet's Disease
por: Huang, Yang, et al.
Publicado: (2019)

DNA CpG methylation in sequential glioblastoma specimens
por: Kraboth, Zoltan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hl23ps8bccnv7f8hj1v8jq5kq6