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Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans

Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affec...

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Autores principales: Calabrese, Cecilia, Corcione, Nadia, Rea, Gaetano, Stefanelli, Francesco, Meoli, Ilernando, Vatrella, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984545/
https://www.ncbi.nlm.nih.gov/pubmed/27383939
http://dx.doi.org/10.1590/S1806-37562016000000043
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author Calabrese, Cecilia
Corcione, Nadia
Rea, Gaetano
Stefanelli, Francesco
Meoli, Ilernando
Vatrella, Alessandro
author_facet Calabrese, Cecilia
Corcione, Nadia
Rea, Gaetano
Stefanelli, Francesco
Meoli, Ilernando
Vatrella, Alessandro
author_sort Calabrese, Cecilia
collection PubMed
description Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting ß(2) agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance.
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spelling pubmed-49845452016-08-25 Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans Calabrese, Cecilia Corcione, Nadia Rea, Gaetano Stefanelli, Francesco Meoli, Ilernando Vatrella, Alessandro J Bras Pneumol Case Report Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting ß(2) agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. Sociedade Brasileira de Pneumologia e Tisiologia 2016 /pmc/articles/PMC4984545/ /pubmed/27383939 http://dx.doi.org/10.1590/S1806-37562016000000043 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Case Report
Calabrese, Cecilia
Corcione, Nadia
Rea, Gaetano
Stefanelli, Francesco
Meoli, Ilernando
Vatrella, Alessandro
Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title_full Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title_fullStr Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title_full_unstemmed Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title_short Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
title_sort impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984545/
https://www.ncbi.nlm.nih.gov/pubmed/27383939
http://dx.doi.org/10.1590/S1806-37562016000000043
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