Cargando…

Evaluation of Angiopoietin-2 as a biomarker in gastric cancer: results from the randomised phase III AVAGAST trial

BACKGROUND: In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hacker, Ulrich T, Escalona-Espinosa, Laura, Consalvo, Nicola, Goede, Valentin, Schiffmann, Lars, Scherer, Stefan J, Hedge, Priti, Van Cutsem, Eric, Coutelle, Oliver, Büning, Hildegard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984795/ https://www.ncbi.nlm.nih.gov/pubmed/27031850 http://dx.doi.org/10.1038/bjc.2016.30

Ejemplares similares

Regional differences in advanced gastric cancer: exploratory analyses of the AVAGAST placebo arm
por: Sawaki, Akira, et al.
Publicado: (2017)

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours
por: Coutelle, O, et al.
Publicado: (2015)

Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy
por: Goede, V, et al.
Publicado: (2010)

Lower Exposure and Faster Clearance of Bevacizumab in Gastric Cancer and the Impact of Patient Variables: Analysis of Individual Data from AVAGAST Phase III Trial
por: Han, Kelong, et al.
Publicado: (2014)

Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives
por: Hacker, Ulrich T., et al.
Publicado: (2020)

Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses
por: Scarpitta, Allan, et al.
Publicado: (2021)

Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study
por: Yamaguchi, Kensei, et al.
Publicado: (2012)

A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition
por: Schiffmann, L M, et al.
Publicado: (2017)

Erratum to: Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study
por: Yamaguchi, Kensei, et al.
Publicado: (2012)

Characterization of a Novel Third-Generation Anti-CD24-CAR against Ovarian Cancer
por: Klapdor, Rüdiger, et al.
Publicado: (2019)

Gene therapy enters the pharma market: The short story of a long journey
por: Büning, Hildegard
Publicado: (2013)

DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations
por: Schnödt, Maria, et al.
Publicado: (2016)

Adeno-Associated Viral Vectors at the Frontier between Tolerance and Immunity
por: Mingozzi, Federico, et al.
Publicado: (2015)

Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors
por: Büning, Hildegard, et al.
Publicado: (2019)

Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors
por: Kiss, Elina A., et al.
Publicado: (2019)

Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction
por: CHEN, SHAOMIN, et al.
Publicado: (2013)

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance
por: Kapiainen, Emmi, et al.
Publicado: (2022)

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity
por: Bartel, Melissa, et al.
Publicado: (2011)

Rational Design of Gene Therapy Vectors
por: Pan, Dao, et al.
Publicado: (2019)

Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells
por: Büning, Hildegard, et al.
Publicado: (2023)

Angiopoietin-2 and Angiopoietin-2/Angiopoietin-1 Ratio as Indicators of Potential Severity of Plasmodium vivax Malaria in Patients with Thrombocytopenia
por: Gomes, Luciano Teixeira, et al.
Publicado: (2014)

Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department
por: Fang, Yingying, et al.
Publicado: (2015)

Correction: Angiopoietin-2 and Angiopoietin-2/Angiopoietin-1 Ratio as Indicators of Potential Severity of Plasmodium vivax Malaria in Patients with Thrombocytopenia
Publicado: (2015)

Angiopoietins and diabetic nephropathy
por: Gnudi, Luigi
Publicado: (2016)

Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis
por: Wang, Kun, et al.
Publicado: (2014)

Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease
por: Tsai, Yi-Chun, et al.
Publicado: (2016)

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
por: Sylvers-Davie, Kelli L., et al.
Publicado: (2021)

Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy
por: Biasco, Luca, et al.
Publicado: (2017)

Light at the end of the tunnel of Corti
por: Hanlon, Kilian, et al.
Publicado: (2023)

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
por: Nguyen, Vicky PKH, et al.
Publicado: (2007)

Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C
por: Hernández-Bartolomé, Ángel, et al.
Publicado: (2016)

Clinical and prognostic significance of circulating levels of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
por: Pestana, Roberto Carmagnani, et al.
Publicado: (2018)

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing
por: Coutelle, Oliver, et al.
Publicado: (2014)

Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells
por: Morgan, Michael A., et al.
Publicado: (2020)

Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat
por: Choi, Jae-Sung, et al.
Publicado: (2013)

Angiopoietin-1 and Angiopoietin-2 Expression Imbalance Influence in Early Period After Subarachnoid Hemorrhage
por: Gu, Hua, et al.
Publicado: (2016)

Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer
por: Yang, Hui, et al.
Publicado: (2021)

Glycation of Tie-2 Inhibits Angiopoietin-1 Signaling Activation and Angiopoietin-1-Induced Angiogenesis
por: Zhou, Haiyan, et al.
Publicado: (2022)

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
por: An, Yu A, et al.
Publicado: (2017)

Evaluation of Serum and Pleural Levels of Angiopoietin-1 and Angiopoietin-2 in Children with Transudative and Exudative Pleural Effusions
por: Sanad, Mohammed, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7ar5gi610sp94s7bnv6jaf12r2