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Long-term impact of preeclampsia on maternal endometrial cancer risk
BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk. METHODS: We conducted a case–control study of 523 Danish women with endometrial cancer and 52 299controls during 19...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984869/ https://www.ncbi.nlm.nih.gov/pubmed/26964032 http://dx.doi.org/10.1038/bjc.2016.55 |
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author | Hallum, Sara Pinborg, Anja Kamper-Jørgensen, Mads |
author_facet | Hallum, Sara Pinborg, Anja Kamper-Jørgensen, Mads |
author_sort | Hallum, Sara |
collection | PubMed |
description | BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk. METHODS: We conducted a case–control study of 523 Danish women with endometrial cancer and 52 299controls during 1978–2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models. RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68–1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29–5.38)). CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer. |
format | Online Article Text |
id | pubmed-4984869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49848692017-03-29 Long-term impact of preeclampsia on maternal endometrial cancer risk Hallum, Sara Pinborg, Anja Kamper-Jørgensen, Mads Br J Cancer Short Communication BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk. METHODS: We conducted a case–control study of 523 Danish women with endometrial cancer and 52 299controls during 1978–2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models. RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68–1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29–5.38)). CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer. Nature Publishing Group 2016-03-29 2016-03-10 /pmc/articles/PMC4984869/ /pubmed/26964032 http://dx.doi.org/10.1038/bjc.2016.55 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Short Communication Hallum, Sara Pinborg, Anja Kamper-Jørgensen, Mads Long-term impact of preeclampsia on maternal endometrial cancer risk |
title | Long-term impact of preeclampsia on maternal endometrial cancer risk |
title_full | Long-term impact of preeclampsia on maternal endometrial cancer risk |
title_fullStr | Long-term impact of preeclampsia on maternal endometrial cancer risk |
title_full_unstemmed | Long-term impact of preeclampsia on maternal endometrial cancer risk |
title_short | Long-term impact of preeclampsia on maternal endometrial cancer risk |
title_sort | long-term impact of preeclampsia on maternal endometrial cancer risk |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984869/ https://www.ncbi.nlm.nih.gov/pubmed/26964032 http://dx.doi.org/10.1038/bjc.2016.55 |
work_keys_str_mv | AT hallumsara longtermimpactofpreeclampsiaonmaternalendometrialcancerrisk AT pinborganja longtermimpactofpreeclampsiaonmaternalendometrialcancerrisk AT kamperjørgensenmads longtermimpactofpreeclampsiaonmaternalendometrialcancerrisk |