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Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis

BACKGROUND: This investigation aimed to assess whether mucinous histology impacts overall (OS) and cancer-specific survival (CSS) in colon cancer. METHODS: Colon cancer patients who underwent surgery between 2004 and 2011 were identified in the Surveillance, Epidemiology, and End Results database. O...

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Autores principales: Warschkow, Rene, Tarantino, Ignazio, Huttner, Felix J, Schmied, Bruno M, Guller, Ulrich, Diener, Markus K, Ulrich, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984906/
https://www.ncbi.nlm.nih.gov/pubmed/26977857
http://dx.doi.org/10.1038/bjc.2016.57
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author Warschkow, Rene
Tarantino, Ignazio
Huttner, Felix J
Schmied, Bruno M
Guller, Ulrich
Diener, Markus K
Ulrich, Alexis
author_facet Warschkow, Rene
Tarantino, Ignazio
Huttner, Felix J
Schmied, Bruno M
Guller, Ulrich
Diener, Markus K
Ulrich, Alexis
author_sort Warschkow, Rene
collection PubMed
description BACKGROUND: This investigation aimed to assess whether mucinous histology impacts overall (OS) and cancer-specific survival (CSS) in colon cancer. METHODS: Colon cancer patients who underwent surgery between 2004 and 2011 were identified in the Surveillance, Epidemiology, and End Results database. OS and CSS were assessed using Cox regression and propensity score methods. RESULTS: Out of 121 628 patients, 12 863 (10.6%) had a mucinous histology. Five-year OS and CSS for mucinous adenocarcinoma were 54.4% (95% CI: 53.4–55.5%) and 66.5% (95% CI: 65.5–67.5%) compared with 60.2% (95% CI: 59.8–60.5%) and 71.9% (95% CI: 71.5–72.2%) for non-mucinous adenocarcinoma (P<0.001). This survival disadvantage disappeared in multivariable analyses (hazard ratio (HR)=1.02, 95% CI: 0.99–1.05, P=0.269 and HR=1.03, 95% CI: 0.99–1.06, P=0.169), and after propensity score matching (OS: HR=0.99, 95% CI: 0.93–1.04, P=0.606 and CSS: HR=0.99, 95% CI:0.92–1.06, P=0.783). CONCLUSIONS: In this population-based investigation, a mucinous histology did not negatively impact survival. Hence, the present study does not provide evidence to change treatment strategies in patients with mucinous adenocarcinoma of the colon.
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spelling pubmed-49849062017-04-26 Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis Warschkow, Rene Tarantino, Ignazio Huttner, Felix J Schmied, Bruno M Guller, Ulrich Diener, Markus K Ulrich, Alexis Br J Cancer Epidemiology BACKGROUND: This investigation aimed to assess whether mucinous histology impacts overall (OS) and cancer-specific survival (CSS) in colon cancer. METHODS: Colon cancer patients who underwent surgery between 2004 and 2011 were identified in the Surveillance, Epidemiology, and End Results database. OS and CSS were assessed using Cox regression and propensity score methods. RESULTS: Out of 121 628 patients, 12 863 (10.6%) had a mucinous histology. Five-year OS and CSS for mucinous adenocarcinoma were 54.4% (95% CI: 53.4–55.5%) and 66.5% (95% CI: 65.5–67.5%) compared with 60.2% (95% CI: 59.8–60.5%) and 71.9% (95% CI: 71.5–72.2%) for non-mucinous adenocarcinoma (P<0.001). This survival disadvantage disappeared in multivariable analyses (hazard ratio (HR)=1.02, 95% CI: 0.99–1.05, P=0.269 and HR=1.03, 95% CI: 0.99–1.06, P=0.169), and after propensity score matching (OS: HR=0.99, 95% CI: 0.93–1.04, P=0.606 and CSS: HR=0.99, 95% CI:0.92–1.06, P=0.783). CONCLUSIONS: In this population-based investigation, a mucinous histology did not negatively impact survival. Hence, the present study does not provide evidence to change treatment strategies in patients with mucinous adenocarcinoma of the colon. Nature Publishing Group 2016-04-26 2016-03-15 /pmc/articles/PMC4984906/ /pubmed/26977857 http://dx.doi.org/10.1038/bjc.2016.57 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Warschkow, Rene
Tarantino, Ignazio
Huttner, Felix J
Schmied, Bruno M
Guller, Ulrich
Diener, Markus K
Ulrich, Alexis
Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title_full Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title_fullStr Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title_full_unstemmed Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title_short Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
title_sort predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984906/
https://www.ncbi.nlm.nih.gov/pubmed/26977857
http://dx.doi.org/10.1038/bjc.2016.57
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