Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis

BACKGROUND: Despite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high toxicity, du...

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Detalles Bibliográficos
Autores principales: Ferreira, Diêgo dos Santos, Faria, Samilla Dornelas, Lopes, Sávia Caldeira de Araújo, Teixeira, Cláudia Salviano, Malachias, Angelo, Magalhães-Paniago, Rogério, de Souza Filho, José Dias, Oliveira, Bruno Luis de Jesus Pinto, Guimarães, Alexander Ramos, Caravan, Peter, Ferreira, Lucas Antônio Miranda, Alves, Ricardo José, Oliveira, Mônica Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984992/
https://www.ncbi.nlm.nih.gov/pubmed/27563241
http://dx.doi.org/10.2147/IJN.S109966

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