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Sildenafil citrate for the management of fetal growth restriction and oligohydramnios

Fetal growth restriction (FGR) and preeclampsia are the major causes of neonatal morbidity and mortality, which affect up to 8% of all pregnancies. The pathogenesis in FGR is an abnormal trophoblastic invasion leading to compromised uteroplacental circulation. However, in spite of this understanding...

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Autores principales: Choudhary, Rana, Desai, Kavita, Parekh, Hetal, Ganla, Kedar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984996/
https://www.ncbi.nlm.nih.gov/pubmed/27563258
http://dx.doi.org/10.2147/IJWH.S108370
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author Choudhary, Rana
Desai, Kavita
Parekh, Hetal
Ganla, Kedar
author_facet Choudhary, Rana
Desai, Kavita
Parekh, Hetal
Ganla, Kedar
author_sort Choudhary, Rana
collection PubMed
description Fetal growth restriction (FGR) and preeclampsia are the major causes of neonatal morbidity and mortality, which affect up to 8% of all pregnancies. The pathogenesis in FGR is an abnormal trophoblastic invasion leading to compromised uteroplacental circulation. However, in spite of this understanding and identification of high-risk patients, the management options are limited. There are some new studies which have demonstrated the role of sildenafil citrate in improving vasodilatation of small myometrial vessels and therefore improvement in amniotic fluid index, fetal weight, and even uterine and umbilical artery Doppler patterns. We report here the case of a 31-year-old female with infertility and preconceptional thin endometrium responding well to sildenafil citrate, followed by conception. However, she presented with an early-onset FGR at 26 weeks of gestation, and again after treatment with sildenafil citrate, showed improvement in amniotic fluid index and fetal weight, finally resulting in delivery of a full-term healthy baby with uneventful neonatal course.
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spelling pubmed-49849962016-08-25 Sildenafil citrate for the management of fetal growth restriction and oligohydramnios Choudhary, Rana Desai, Kavita Parekh, Hetal Ganla, Kedar Int J Womens Health Case Report Fetal growth restriction (FGR) and preeclampsia are the major causes of neonatal morbidity and mortality, which affect up to 8% of all pregnancies. The pathogenesis in FGR is an abnormal trophoblastic invasion leading to compromised uteroplacental circulation. However, in spite of this understanding and identification of high-risk patients, the management options are limited. There are some new studies which have demonstrated the role of sildenafil citrate in improving vasodilatation of small myometrial vessels and therefore improvement in amniotic fluid index, fetal weight, and even uterine and umbilical artery Doppler patterns. We report here the case of a 31-year-old female with infertility and preconceptional thin endometrium responding well to sildenafil citrate, followed by conception. However, she presented with an early-onset FGR at 26 weeks of gestation, and again after treatment with sildenafil citrate, showed improvement in amniotic fluid index and fetal weight, finally resulting in delivery of a full-term healthy baby with uneventful neonatal course. Dove Medical Press 2016-08-09 /pmc/articles/PMC4984996/ /pubmed/27563258 http://dx.doi.org/10.2147/IJWH.S108370 Text en © 2016 Choudhary et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Choudhary, Rana
Desai, Kavita
Parekh, Hetal
Ganla, Kedar
Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title_full Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title_fullStr Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title_full_unstemmed Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title_short Sildenafil citrate for the management of fetal growth restriction and oligohydramnios
title_sort sildenafil citrate for the management of fetal growth restriction and oligohydramnios
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984996/
https://www.ncbi.nlm.nih.gov/pubmed/27563258
http://dx.doi.org/10.2147/IJWH.S108370
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