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Calcium Dynamics of Ex Vivo Long-Term Cultured CD8(+) T Cells Are Regulated by Changes in Redox Metabolism

T cells reach a state of replicative senescence characterized by a decreased ability to proliferate and respond to foreign antigens. Calcium release associated with TCR engagement is widely used as a surrogate measure of T cell response. Using an ex vivo culture model that partially replicates featu...

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Detalles Bibliográficos
Autores principales:	Rivet, Catherine A., Kniss-James, Ariel S., Gran, Margaret A., Potnis, Anish, Hill, Abby, Lu, Hang, Kemp, Melissa L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985122/ https://www.ncbi.nlm.nih.gov/pubmed/27526200 http://dx.doi.org/10.1371/journal.pone.0159248

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