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Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer

OBJECTIVE: To investigate interobserver and inter-CT variations in using the active breath co-ordinate technique in the determination of clinical tumour volume (CTV) and normal organs in post-operative gastric cancer radiotherapy. METHODS: Ten gastric cancer patients were enrolled in our study, and...

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Autores principales: Li, Gui-Chao, Zhang, Zhen, Ma, Xue-Jun, Yu, Xiao-Li, Hu, Wei-Gang, Wang, Jia-Zhou, Li, Qi-Wen, Liang, Li-Ping, Shen, Li-Jun, Zhang, Hui, Fan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985190/
https://www.ncbi.nlm.nih.gov/pubmed/26654032
http://dx.doi.org/10.1259/bjr.20150332
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author Li, Gui-Chao
Zhang, Zhen
Ma, Xue-Jun
Yu, Xiao-Li
Hu, Wei-Gang
Wang, Jia-Zhou
Li, Qi-Wen
Liang, Li-Ping
Shen, Li-Jun
Zhang, Hui
Fan, Ming
author_facet Li, Gui-Chao
Zhang, Zhen
Ma, Xue-Jun
Yu, Xiao-Li
Hu, Wei-Gang
Wang, Jia-Zhou
Li, Qi-Wen
Liang, Li-Ping
Shen, Li-Jun
Zhang, Hui
Fan, Ming
author_sort Li, Gui-Chao
collection PubMed
description OBJECTIVE: To investigate interobserver and inter-CT variations in using the active breath co-ordinate technique in the determination of clinical tumour volume (CTV) and normal organs in post-operative gastric cancer radiotherapy. METHODS: Ten gastric cancer patients were enrolled in our study, and four radiation oncologists independently determined the CTVs and organs at risk based on the CT simulation data. To determine interobserver and inter-CT variation, we evaluated the maximum dimensions, derived volume and distance between the centres of mass (CMs) of the CTVs. We assessed the reliability in CTV determination among the observers by conformity index (CI). RESULTS: The average volumes ± standard deviation (cm(3)) of the CTV, liver, left kidney and right kidney were 674 ± 138 (range, 332–969), 1000 ± 138 (range, 714–1320), 149 ± 13 (range, 104–183) and 141 ± 21 (range, 110–186) cm(3), respectively. The average inter-CT distances between the CMs of the CTV, liver, left kidney and right kidney were 0.40, 0.56, 0.65 and 0.6 cm, respectively; the interobserver values were 0.98, 0.53, 0.16 and 0.15 cm, respectively. CONCLUSIONS: In the volume size of CTV for post-operative gastric cancer, there were significant variations among multiple observers, whereas there was no variation between different CTs. The slices in which variations more likely occur were the slices of the lower verge of the hilum of the spleen and porta hepatis, then the paraoesophageal lymph nodes region and abdominal aorta, and the inferior vena cava, and the variation in the craniocaudal orientation from the interobserver was more predominant than that from inter-CT. ADVANCES IN KNOWLEDGE: First, this is the first study to evaluate the interobserver and inter-CT variations in the determination of the CTV and normal organs in gastric cancer with the use of the active breath co-ordinate technique. Second, we analysed the region where variations most likely occur. Third, we investigated the influence of interobserver variation on the dose distribution.
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spelling pubmed-49851902016-08-29 Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer Li, Gui-Chao Zhang, Zhen Ma, Xue-Jun Yu, Xiao-Li Hu, Wei-Gang Wang, Jia-Zhou Li, Qi-Wen Liang, Li-Ping Shen, Li-Jun Zhang, Hui Fan, Ming Br J Radiol Full Paper OBJECTIVE: To investigate interobserver and inter-CT variations in using the active breath co-ordinate technique in the determination of clinical tumour volume (CTV) and normal organs in post-operative gastric cancer radiotherapy. METHODS: Ten gastric cancer patients were enrolled in our study, and four radiation oncologists independently determined the CTVs and organs at risk based on the CT simulation data. To determine interobserver and inter-CT variation, we evaluated the maximum dimensions, derived volume and distance between the centres of mass (CMs) of the CTVs. We assessed the reliability in CTV determination among the observers by conformity index (CI). RESULTS: The average volumes ± standard deviation (cm(3)) of the CTV, liver, left kidney and right kidney were 674 ± 138 (range, 332–969), 1000 ± 138 (range, 714–1320), 149 ± 13 (range, 104–183) and 141 ± 21 (range, 110–186) cm(3), respectively. The average inter-CT distances between the CMs of the CTV, liver, left kidney and right kidney were 0.40, 0.56, 0.65 and 0.6 cm, respectively; the interobserver values were 0.98, 0.53, 0.16 and 0.15 cm, respectively. CONCLUSIONS: In the volume size of CTV for post-operative gastric cancer, there were significant variations among multiple observers, whereas there was no variation between different CTs. The slices in which variations more likely occur were the slices of the lower verge of the hilum of the spleen and porta hepatis, then the paraoesophageal lymph nodes region and abdominal aorta, and the inferior vena cava, and the variation in the craniocaudal orientation from the interobserver was more predominant than that from inter-CT. ADVANCES IN KNOWLEDGE: First, this is the first study to evaluate the interobserver and inter-CT variations in the determination of the CTV and normal organs in gastric cancer with the use of the active breath co-ordinate technique. Second, we analysed the region where variations most likely occur. Third, we investigated the influence of interobserver variation on the dose distribution. The British Institute of Radiology. 2016-02 2016-01-08 /pmc/articles/PMC4985190/ /pubmed/26654032 http://dx.doi.org/10.1259/bjr.20150332 Text en © 2015 The Authors. Published by the British Institute of Radiology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted non-commercial reuse, provided the original author and source are credited.
spellingShingle Full Paper
Li, Gui-Chao
Zhang, Zhen
Ma, Xue-Jun
Yu, Xiao-Li
Hu, Wei-Gang
Wang, Jia-Zhou
Li, Qi-Wen
Liang, Li-Ping
Shen, Li-Jun
Zhang, Hui
Fan, Ming
Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title_full Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title_fullStr Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title_full_unstemmed Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title_short Variations in CT determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
title_sort variations in ct determination of target volume with active breath co-ordinate in radiotherapy for post-operative gastric cancer
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985190/
https://www.ncbi.nlm.nih.gov/pubmed/26654032
http://dx.doi.org/10.1259/bjr.20150332
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