α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels

Orai1 forms a highly calcium-selective pore of the calcium release activated channel, and α-SNAP is necessary for its function. Here we show that α-SNAP regulates on-site assembly of Orai1 dimers into calcium-selective multimers. We find that Orai1 is a dimer in resting primary mouse embryonic fibro...

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Detalles Bibliográficos
Autores principales: Li, Peiyao, Miao, Yong, Dani, Adish, Vig, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985256/
https://www.ncbi.nlm.nih.gov/pubmed/27335124
http://dx.doi.org/10.1091/mbc.E16-03-0163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985256/
https://www.ncbi.nlm.nih.gov/pubmed/27335124
http://dx.doi.org/10.1091/mbc.E16-03-0163

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