The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2’s function

Leiomodin is a potent actin nucleator related to tropomodulin, a capping protein localized at the pointed end of the thin filaments. Mutations in leiomodin-3 are associated with lethal nemaline myopathy in humans, and leiomodin-2–knockout mice present with dilated cardiomyopathy. The arrangement of...

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Detalles Bibliográficos
Autores principales: Ly, Thu, Moroz, Natalia, Pappas, Christopher T., Novak, Stefanie M., Tolkatchev, Dmitri, Wooldridge, Dayton, Mayfield, Rachel M., Helms, Gregory, Gregorio, Carol C., Kostyukova, Alla S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985258/
https://www.ncbi.nlm.nih.gov/pubmed/27307584
http://dx.doi.org/10.1091/mbc.E16-03-0200

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