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Adaptation in protein fitness landscapes is facilitated by indirect paths

The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph in...

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Detalles Bibliográficos
Autores principales: Wu, Nicholas C, Dai, Lei, Olson, C Anders, Lloyd-Smith, James O, Sun, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985287/
https://www.ncbi.nlm.nih.gov/pubmed/27391790
http://dx.doi.org/10.7554/eLife.16965

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