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Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis
OBJECTIVE: To investigate the changes of retinal nerve fiber layer (RNFL) thickness in obstructive sleep apnea syndrome (OSAS) patients. METHODS: Relevant studies were selected from 3 major literature databases (PubMed, Cochrane Library, and EMBASE) without language restriction. Main inclusion crite...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985322/ https://www.ncbi.nlm.nih.gov/pubmed/27512867 http://dx.doi.org/10.1097/MD.0000000000004499 |
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author | Sun, Cheng-Lin Zhou, Li-Xiao Dang, Yalong Huo, Yin-Ping Shi, Lei Chang, Yong-Jie |
author_facet | Sun, Cheng-Lin Zhou, Li-Xiao Dang, Yalong Huo, Yin-Ping Shi, Lei Chang, Yong-Jie |
author_sort | Sun, Cheng-Lin |
collection | PubMed |
description | OBJECTIVE: To investigate the changes of retinal nerve fiber layer (RNFL) thickness in obstructive sleep apnea syndrome (OSAS) patients. METHODS: Relevant studies were selected from 3 major literature databases (PubMed, Cochrane Library, and EMBASE) without language restriction. Main inclusion criteria is that a case-control study in which RNFL thickness was measured by a commercial available optical coherence tomography (OCT) in OSAS patients. Meta-analysis was performed using STATA 12.0 software. Efficacy estimates were evaluated by weighted mean difference with corresponding 95% confidence intervals (CIs). Primary outcome evaluations were: the average changes of RNFL thickness in total OSAS patients, subgroup analysis of RNFL thickness changes in patients of different OSAS stages, and subgroup analysis of 4-quadrant RNFL thickness changes in total OSAS patients. RESULTS: Of the initial 327 literatures, 8 case-control studies with 763 eyes of OSA patients and 474 eyes of healthy controls were included (NOS scores ≥6). For the people of total OSAS, there had an average 2.92 μm decreased RNFL thickness compared with controls (95% CI: −4.61 to −1.24, P = 0.001). For subgroup analysis of OSAS in different stages, the average changes of RNFL thickness in mild, moderate, severe, and moderate to severe OSAS were 2.05 (95% CI: −4.40 to 0.30, P = 0.088), 2.32 (95% CI: −5.04 to 0.40, P = 0.094), 4.21 (95% CI: −8.36 to −0.06, P = 0.047), and 4.02 (95% CI: −7.65 to −0.40, P = 0.03), respectively. For subgroup analysis of 4-quadrant, the average changes of RNFL thickness in Superior, Nasal, Inferior, and Temporal quadrant were 2.43 (95% CI: −4.28 to −0.57, P = 0.01), 1.41 (95% CI: −3.33 to 0.51, P = 0.151), 3.75 (95% CI: −6.92 to −0.59, P = 0.02), and 0.98 (95% CI: −2.49 to 0.53, P = 0.203), respectively. CONCLUSION: Our study suggests that RNFL thickness in OSAS patients is much thinner than healthy population, especially in superior and inferior quadrant. The impact of OSAS disease on RNFL and visual function should be taken seriously in the further study. |
format | Online Article Text |
id | pubmed-4985322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49853222016-08-26 Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis Sun, Cheng-Lin Zhou, Li-Xiao Dang, Yalong Huo, Yin-Ping Shi, Lei Chang, Yong-Jie Medicine (Baltimore) 5800 OBJECTIVE: To investigate the changes of retinal nerve fiber layer (RNFL) thickness in obstructive sleep apnea syndrome (OSAS) patients. METHODS: Relevant studies were selected from 3 major literature databases (PubMed, Cochrane Library, and EMBASE) without language restriction. Main inclusion criteria is that a case-control study in which RNFL thickness was measured by a commercial available optical coherence tomography (OCT) in OSAS patients. Meta-analysis was performed using STATA 12.0 software. Efficacy estimates were evaluated by weighted mean difference with corresponding 95% confidence intervals (CIs). Primary outcome evaluations were: the average changes of RNFL thickness in total OSAS patients, subgroup analysis of RNFL thickness changes in patients of different OSAS stages, and subgroup analysis of 4-quadrant RNFL thickness changes in total OSAS patients. RESULTS: Of the initial 327 literatures, 8 case-control studies with 763 eyes of OSA patients and 474 eyes of healthy controls were included (NOS scores ≥6). For the people of total OSAS, there had an average 2.92 μm decreased RNFL thickness compared with controls (95% CI: −4.61 to −1.24, P = 0.001). For subgroup analysis of OSAS in different stages, the average changes of RNFL thickness in mild, moderate, severe, and moderate to severe OSAS were 2.05 (95% CI: −4.40 to 0.30, P = 0.088), 2.32 (95% CI: −5.04 to 0.40, P = 0.094), 4.21 (95% CI: −8.36 to −0.06, P = 0.047), and 4.02 (95% CI: −7.65 to −0.40, P = 0.03), respectively. For subgroup analysis of 4-quadrant, the average changes of RNFL thickness in Superior, Nasal, Inferior, and Temporal quadrant were 2.43 (95% CI: −4.28 to −0.57, P = 0.01), 1.41 (95% CI: −3.33 to 0.51, P = 0.151), 3.75 (95% CI: −6.92 to −0.59, P = 0.02), and 0.98 (95% CI: −2.49 to 0.53, P = 0.203), respectively. CONCLUSION: Our study suggests that RNFL thickness in OSAS patients is much thinner than healthy population, especially in superior and inferior quadrant. The impact of OSAS disease on RNFL and visual function should be taken seriously in the further study. Wolters Kluwer Health 2016-08-12 /pmc/articles/PMC4985322/ /pubmed/27512867 http://dx.doi.org/10.1097/MD.0000000000004499 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0 |
spellingShingle | 5800 Sun, Cheng-Lin Zhou, Li-Xiao Dang, Yalong Huo, Yin-Ping Shi, Lei Chang, Yong-Jie Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title | Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title_full | Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title_fullStr | Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title_full_unstemmed | Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title_short | Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis |
title_sort | decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: a meta-analysis |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985322/ https://www.ncbi.nlm.nih.gov/pubmed/27512867 http://dx.doi.org/10.1097/MD.0000000000004499 |
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