The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME...

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Detalles Bibliográficos
Autores principales: Nettersheim, Daniel, Arndt, Isabell, Sharma, Rakesh, Riesenberg, Stefanie, Jostes, Sina, Schneider, Simon, Hölzel, Michael, Kristiansen, Glen, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985348/
https://www.ncbi.nlm.nih.gov/pubmed/27441500
http://dx.doi.org/10.1038/bjc.2016.187

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