ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

BACKGROUND: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood. METHODS: We created novel A...

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Detalles Bibliográficos
Autores principales: Vaidyanathan, Aparajitha, Sawers, Lynne, Gannon, Anne-Louise, Chakravarty, Probir, Scott, Alison L, Bray, Susan E, Ferguson, Michelle J, Smith, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985349/
https://www.ncbi.nlm.nih.gov/pubmed/27415012
http://dx.doi.org/10.1038/bjc.2016.203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985349/
https://www.ncbi.nlm.nih.gov/pubmed/27415012
http://dx.doi.org/10.1038/bjc.2016.203

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