Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling

Head and neck squamous cell carcinoma (HNSCC) patients have a poor prognosis, with invasion and metastasis as major causes of mortality. The phosphatidylinositol 3-kinase (PI3K) pathway regulates a wide range of cellular processes crucial for tumorigenesis, and PIK3CA amplification and mutation are...

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Detalles Bibliográficos
Autores principales: Du, L, Chen, X, Cao, Y, Lu, L, Zhang, F, Bornstein, S, Li, Y, Owens, P, Malkoski, S, Said, S, Kulesz-Martin, M, Gross, N, Wang, X-J, Lu, S-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985507/
https://www.ncbi.nlm.nih.gov/pubmed/26876212
http://dx.doi.org/10.1038/onc.2016.1

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