Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil

Autoimmune haemolytic anaemia is not a well-recognised complication of sarcoidosis. We describe the case of a 30-year-old female who presented with acute warm haemolytic anaemia and widespread lymphadenopathy. Sarcoidosis was diagnosed on lymph node biopsy and further investigation. The haemolytic a...

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Autores principales: Green, Sarah, Partridge, Erica, Idedevbo, Edore, Borg, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985568/
https://www.ncbi.nlm.nih.gov/pubmed/27563474
http://dx.doi.org/10.1155/2016/9495761
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author Green, Sarah
Partridge, Erica
Idedevbo, Edore
Borg, Anton
author_facet Green, Sarah
Partridge, Erica
Idedevbo, Edore
Borg, Anton
author_sort Green, Sarah
collection PubMed
description Autoimmune haemolytic anaemia is not a well-recognised complication of sarcoidosis. We describe the case of a 30-year-old female who presented with acute warm haemolytic anaemia and widespread lymphadenopathy. Sarcoidosis was diagnosed on lymph node biopsy and further investigation. The haemolytic anaemia responded only to a high dose of steroids. Evidence regarding treatment of steroid refractory autoimmune haemolysis secondary to sarcoidosis is lacking. Based on the emergent evidence that both disorders share common immunopathogenic mechanisms involving Th1 and Th17 lymphocytes, our patient was given rituximab and mycophenolate mofetil to successfully suppress the haemolysis and sarcoid activity.
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spelling pubmed-49855682016-08-25 Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil Green, Sarah Partridge, Erica Idedevbo, Edore Borg, Anton Case Rep Hematol Case Report Autoimmune haemolytic anaemia is not a well-recognised complication of sarcoidosis. We describe the case of a 30-year-old female who presented with acute warm haemolytic anaemia and widespread lymphadenopathy. Sarcoidosis was diagnosed on lymph node biopsy and further investigation. The haemolytic anaemia responded only to a high dose of steroids. Evidence regarding treatment of steroid refractory autoimmune haemolysis secondary to sarcoidosis is lacking. Based on the emergent evidence that both disorders share common immunopathogenic mechanisms involving Th1 and Th17 lymphocytes, our patient was given rituximab and mycophenolate mofetil to successfully suppress the haemolysis and sarcoid activity. Hindawi Publishing Corporation 2016 2016-08-02 /pmc/articles/PMC4985568/ /pubmed/27563474 http://dx.doi.org/10.1155/2016/9495761 Text en Copyright © 2016 Sarah Green et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Green, Sarah
Partridge, Erica
Idedevbo, Edore
Borg, Anton
Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title_full Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title_fullStr Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title_full_unstemmed Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title_short Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil
title_sort steroid refractory autoimmune haemolytic anaemia secondary to sarcoidosis successfully treated with rituximab and mycophenolate mofetil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985568/
https://www.ncbi.nlm.nih.gov/pubmed/27563474
http://dx.doi.org/10.1155/2016/9495761
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AT idedevboedore steroidrefractoryautoimmunehaemolyticanaemiasecondarytosarcoidosissuccessfullytreatedwithrituximabandmycophenolatemofetil
AT borganton steroidrefractoryautoimmunehaemolyticanaemiasecondarytosarcoidosissuccessfullytreatedwithrituximabandmycophenolatemofetil

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