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Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function

Tryptophan is an essential amino acid for hosts and pathogens. The liver enzyme tryptophan 2,3-dioxygenase (TDO) provokes, by its ability to degrade tryptophan to N-formylkynurenine, the precursor of the immune-relevant kynurenines, direct and indirect antimicrobial and immunoregulatory states. Up t...

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Detalles Bibliográficos
Autores principales:	Elbers, Frank, Woite, Claudia, Antoni, Valentina, Stein, Sara, Funakoshi, Hiroshi, Nakamura, Toshikazu, Schares, Gereon, Däubener, Walter, Eller, Silvia K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985583/ https://www.ncbi.nlm.nih.gov/pubmed/27563172 http://dx.doi.org/10.1155/2016/1638916

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