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Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis

GxGD‐type intramembrane cleaving proteases (I‐CLiPs) form a family of proteolytic enzymes that feature an aspartate‐based catalytic mechanism. Yet, they structurally and functionally largely differ from the classical pepsin‐like aspartic proteases. Among them are the archaeal enzyme FlaK, processing...

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Detalles Bibliográficos
Autores principales:	Coburger, Ina, Schaub, Yvonne, Roeser, Dirk, Hardes, Kornelia, Maeder, Patrick, Klee, Nina, Steinmetzer, Torsten, Imhof, Diana, Diederich, Wibke E., Than, Manuel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985597/ https://www.ncbi.nlm.nih.gov/pubmed/27038342 http://dx.doi.org/10.1002/mbo3.358

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