Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer

While aberrant JAK/STAT signaling is crucial to the development of gastric cancer (GC), its effects on epigenetic alterations of its transcriptional targets remains unclear. In this study, by expression microarrays coupled with bioinformatic analyses, we identified a putative STAT3 target gene, NR4A...

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Detalles Bibliográficos
Autores principales: Yeh, Chung-Min, Chang, Liang-Yu, Lin, Shu-Hui, Chou, Jian-Liang, Hsieh, Hsiao-Yen, Zeng, Li-Han, Chuang, Sheng-Yu, Wang, Hsiao-Wen, Dittner, Claudia, Lin, Cheng-Yu, Lin, Jora M. J., Huang, Yao-Ting, Ng, Enders K. W., Cheng, Alfred S. L., Wu, Shu-Fen, Lin, Jiayuh, Yeh, Kun-Tu, Chan, Michael W. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985659/
https://www.ncbi.nlm.nih.gov/pubmed/27528092
http://dx.doi.org/10.1038/srep31690

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