Cargando…

The structural origin of metabolic quantitative diversity

Relationship between structural variants of enzymes and metabolic phenotypes in human population was investigated based on the association study of metabolite quantitative traits with whole genome sequence data for 512 individuals from a population cohort. We identified five significant associations...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koshiba, Seizo, Motoike, Ikuko, Kojima, Kaname, Hasegawa, Takanori, Shirota, Matsuyuki, Saito, Tomo, Saigusa, Daisuke, Danjoh, Inaho, Katsuoka, Fumiki, Ogishima, Soichi, Kawai, Yosuke, Yamaguchi-Kabata, Yumi, Sakurai, Miyuki, Hirano, Sachiko, Nakata, Junichi, Motohashi, Hozumi, Hozawa, Atsushi, Kuriyama, Shinichi, Minegishi, Naoko, Nagasaki, Masao, Takai-Igarashi, Takako, Fuse, Nobuo, Kiyomoto, Hideyasu, Sugawara, Junichi, Suzuki, Yoichi, Kure, Shigeo, Yaegashi, Nobuo, Tanabe, Osamu, Kinoshita, Kengo, Yasuda, Jun, Yamamoto, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985752/ https://www.ncbi.nlm.nih.gov/pubmed/27528366 http://dx.doi.org/10.1038/srep31463

Ejemplares similares

3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome
por: Tadaka, Shu, et al.
Publicado: (2019)

Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population
por: Koshiba, Seizo, et al.
Publicado: (2020)

Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals
por: Nagasaki, Masao, et al.
Publicado: (2015)

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy
por: Sugawara, Junichi, et al.
Publicado: (2019)

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
por: Yamada, Mitsuhiro, et al.
Publicado: (2021)

Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population
por: Motoike, Ikuko N, et al.
Publicado: (2014)

Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing
por: Nagasaki, Masao, et al.
Publicado: (2019)

Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project
por: Fuse, Nobuo, et al.
Publicado: (2019)

Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2)
por: Tokunaga, Hideki, et al.
Publicado: (2021)

Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
por: Sugawara, Junichi, et al.
Publicado: (2022)

Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project
por: Yasuda, Jun, et al.
Publicado: (2018)

jMorp: Japanese Multi Omics Reference Panel
por: Tadaka, Shu, et al.
Publicado: (2018)

Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study
por: Fuse, Nobuo, et al.
Publicado: (2022)

Plasma metabolic disturbances during pregnancy and postpartum in women with depression
por: Yu, Zhiqian, et al.
Publicado: (2022)

jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population
por: Tadaka, Shu, et al.
Publicado: (2020)

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
por: Ogishima, Soichi, et al.
Publicado: (2021)

Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background
por: Taira, Makiko, et al.
Publicado: (2023)

Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis
por: Yamauchi, Takafumi, et al.
Publicado: (2021)

Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project
por: Saito, Sakae, et al.
Publicado: (2021)

Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection
por: Takahashi, Yuta, et al.
Publicado: (2020)

Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals
por: Nagaoka, Shinichi, et al.
Publicado: (2021)

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery
por: Saigusa, Daisuke, et al.
Publicado: (2016)

Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling
por: Hishinuma, Eiji, et al.
Publicado: (2023)

Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study
por: Mizuno, Satoshi, et al.
Publicado: (2023)

Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs
por: Sakurai-Yageta, Mika, et al.
Publicado: (2021)

Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer
por: Hishinuma, Eiji, et al.
Publicado: (2021)

Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing
por: Mimori, Takahiro, et al.
Publicado: (2018)

A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants
por: Ohneda, Kinuko, et al.
Publicado: (2022)

Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design
por: Takai-Igarashi, Takako, et al.
Publicado: (2017)

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia
por: Nishizawa, Ayako, et al.
Publicado: (2020)

Pathological variants in genes associated with disorders of sex development and central causes of hypogonadism in a whole-genome reference panel of 8380 Japanese individuals
por: Shiga, Naomi, et al.
Publicado: (2022)

A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization
por: Sakurai-Yageta, Mika, et al.
Publicado: (2019)

iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing
por: Yamaguchi-Kabata, Yumi, et al.
Publicado: (2015)

Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
por: Saigusa, Daisuke, et al.
Publicado: (2020)

Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals
por: Kawai, Yosuke, et al.
Publicado: (2015)

Factors associated with postpartum smoking relapse at early postpartum period of Japanese women in the Japan Environmental and Children’s Study
por: Anai, Akane, et al.
Publicado: (2023)

Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer’s Disease
por: Mizuno, Satoshi, et al.
Publicado: (2016)

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective
por: Kuriyama, Shinichi, et al.
Publicado: (2020)

Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values
por: Saigusa, Daisuke, et al.
Publicado: (2021)

Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study
por: Takase, Masato, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p5lmhqa9uha8cvj9vo08o3dmph