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False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review

OBJECTIVE: Many published meta-analyses are underpowered. We explored the role of trial sequential analysis (TSA) in assessing the reliability of conclusions in underpowered meta-analyses. METHODS: We screened The Cochrane Database of Systematic Reviews and selected 100 meta-analyses with a binary o...

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Detalles Bibliográficos
Autores principales:	Imberger, Georgina, Thorlund, Kristian, Gluud, Christian, Wetterslev, Jørn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Public Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985805/ https://www.ncbi.nlm.nih.gov/pubmed/27519923 http://dx.doi.org/10.1136/bmjopen-2016-011890

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