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False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review
OBJECTIVE: Many published meta-analyses are underpowered. We explored the role of trial sequential analysis (TSA) in assessing the reliability of conclusions in underpowered meta-analyses. METHODS: We screened The Cochrane Database of Systematic Reviews and selected 100 meta-analyses with a binary o...
Autores principales: | Imberger, Georgina, Thorlund, Kristian, Gluud, Christian, Wetterslev, Jørn |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985805/ https://www.ncbi.nlm.nih.gov/pubmed/27519923 http://dx.doi.org/10.1136/bmjopen-2016-011890 |
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