TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center of the pathogenesis of the development of ALI. Interleukin-1β (IL-1β) is one of the key pro-inflammatory mediators, and its maturation...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xingying, Qian, Yongbing, Li, Zhigang, Fan, Erica K., Li, Yuehua, Wu, Liang, Billiar, Timothy R., Wilson, Mark A., Shi, Xueyin, Fan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985817/
https://www.ncbi.nlm.nih.gov/pubmed/27526865
http://dx.doi.org/10.1038/srep31663

Ejemplares similares

Ejemplares similares