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Drug combinatorics and side effect estimation on the signed human drug-target network
BACKGROUND: The mode of action of a drug on its targets can often be classified as being positive (activator, potentiator, agonist, etc.) or negative (inhibitor, blocker, antagonist, etc.). The signed edges of a drug-target network can be used to investigate the combined mechanisms of action of mult...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986181/ https://www.ncbi.nlm.nih.gov/pubmed/27526853 http://dx.doi.org/10.1186/s12918-016-0326-8 |