A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K(2)CO(3) as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The comb...

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Detalles Bibliográficos
Autores principales: Disale, Shamrao, Kale, Sandip, Abraham, George, Kahandal, Sandeep, Sawarkar, Ashish N., Gawande, Manoj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986413/
https://www.ncbi.nlm.nih.gov/pubmed/27579301
http://dx.doi.org/10.3389/fchem.2016.00035
Descripción
Sumario:An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K(2)CO(3) as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K(2)CO(3) in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.

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