A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K(2)CO(3) as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The comb...

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Autores principales: Disale, Shamrao, Kale, Sandip, Abraham, George, Kahandal, Sandeep, Sawarkar, Ashish N., Gawande, Manoj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986413/
https://www.ncbi.nlm.nih.gov/pubmed/27579301
http://dx.doi.org/10.3389/fchem.2016.00035
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author Disale, Shamrao
Kale, Sandip
Abraham, George
Kahandal, Sandeep
Sawarkar, Ashish N.
Gawande, Manoj B.
author_facet Disale, Shamrao
Kale, Sandip
Abraham, George
Kahandal, Sandeep
Sawarkar, Ashish N.
Gawande, Manoj B.
author_sort Disale, Shamrao
collection PubMed
description An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K(2)CO(3) as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K(2)CO(3) in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.
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spelling pubmed-49864132016-08-30 A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System Disale, Shamrao Kale, Sandip Abraham, George Kahandal, Sandeep Sawarkar, Ashish N. Gawande, Manoj B. Front Chem Chemistry An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K(2)CO(3) as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K(2)CO(3) in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations. Frontiers Media S.A. 2016-08-16 /pmc/articles/PMC4986413/ /pubmed/27579301 http://dx.doi.org/10.3389/fchem.2016.00035 Text en Copyright © 2016 Disale, Kale, Abraham, Kahandal, Sawarkar and Gawande. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Disale, Shamrao
Kale, Sandip
Abraham, George
Kahandal, Sandeep
Sawarkar, Ashish N.
Gawande, Manoj B.
A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title_full A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title_fullStr A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title_full_unstemmed A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title_short A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
title_sort sustainable and efficient synthesis of benzyl phosphonates using peg/ki catalytic system
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986413/
https://www.ncbi.nlm.nih.gov/pubmed/27579301
http://dx.doi.org/10.3389/fchem.2016.00035
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