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BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986521/ https://www.ncbi.nlm.nih.gov/pubmed/27432941 http://dx.doi.org/10.1084/jem.20150577 |
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author | Parsa, Roham Lund, Harald Georgoudaki, Anna-Maria Zhang, Xing-Mei Ortlieb Guerreiro-Cacais, André Grommisch, David Warnecke, Andreas Croxford, Andrew L. Jagodic, Maja Becher, Burkhard Karlsson, Mikael C.I. Harris, Robert A. |
author_facet | Parsa, Roham Lund, Harald Georgoudaki, Anna-Maria Zhang, Xing-Mei Ortlieb Guerreiro-Cacais, André Grommisch, David Warnecke, Andreas Croxford, Andrew L. Jagodic, Maja Becher, Burkhard Karlsson, Mikael C.I. Harris, Robert A. |
author_sort | Parsa, Roham |
collection | PubMed |
description | Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied immune activation after adjuvant administration. The initial neutropenic state fostered an environment of increased dendritic cell activation and T cell–derived IL-17 production. Interestingly, neutropenic lysozyme 2–diphtheria toxin A mice exhibited striking EG and amplified neutrophil recruitment to the lymph nodes (LNs) that was dependent on IL-17–induced prostaglandin activity. The recruited neutrophils secreted a B cell–activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. Reduction of neutrophil functions via granulocyte colony-stimulating factor neutralization significantly diminished plasma cell formation, directly linking EG with the humoral immune response. We conclude that neutrophils are capable of directly regulating T cell–dependent B cell responses in the LN. |
format | Online Article Text |
id | pubmed-4986521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49865212017-01-25 BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis Parsa, Roham Lund, Harald Georgoudaki, Anna-Maria Zhang, Xing-Mei Ortlieb Guerreiro-Cacais, André Grommisch, David Warnecke, Andreas Croxford, Andrew L. Jagodic, Maja Becher, Burkhard Karlsson, Mikael C.I. Harris, Robert A. J Exp Med Research Articles Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied immune activation after adjuvant administration. The initial neutropenic state fostered an environment of increased dendritic cell activation and T cell–derived IL-17 production. Interestingly, neutropenic lysozyme 2–diphtheria toxin A mice exhibited striking EG and amplified neutrophil recruitment to the lymph nodes (LNs) that was dependent on IL-17–induced prostaglandin activity. The recruited neutrophils secreted a B cell–activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. Reduction of neutrophil functions via granulocyte colony-stimulating factor neutralization significantly diminished plasma cell formation, directly linking EG with the humoral immune response. We conclude that neutrophils are capable of directly regulating T cell–dependent B cell responses in the LN. The Rockefeller University Press 2016-07-25 /pmc/articles/PMC4986521/ /pubmed/27432941 http://dx.doi.org/10.1084/jem.20150577 Text en © 2016 Parsa et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Parsa, Roham Lund, Harald Georgoudaki, Anna-Maria Zhang, Xing-Mei Ortlieb Guerreiro-Cacais, André Grommisch, David Warnecke, Andreas Croxford, Andrew L. Jagodic, Maja Becher, Burkhard Karlsson, Mikael C.I. Harris, Robert A. BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title | BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title_full | BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title_fullStr | BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title_full_unstemmed | BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title_short | BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
title_sort | baff-secreting neutrophils drive plasma cell responses during emergency granulopoiesis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986521/ https://www.ncbi.nlm.nih.gov/pubmed/27432941 http://dx.doi.org/10.1084/jem.20150577 |
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