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BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis

Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied...

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Autores principales: Parsa, Roham, Lund, Harald, Georgoudaki, Anna-Maria, Zhang, Xing-Mei, Ortlieb Guerreiro-Cacais, André, Grommisch, David, Warnecke, Andreas, Croxford, Andrew L., Jagodic, Maja, Becher, Burkhard, Karlsson, Mikael C.I., Harris, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986521/
https://www.ncbi.nlm.nih.gov/pubmed/27432941
http://dx.doi.org/10.1084/jem.20150577
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author Parsa, Roham
Lund, Harald
Georgoudaki, Anna-Maria
Zhang, Xing-Mei
Ortlieb Guerreiro-Cacais, André
Grommisch, David
Warnecke, Andreas
Croxford, Andrew L.
Jagodic, Maja
Becher, Burkhard
Karlsson, Mikael C.I.
Harris, Robert A.
author_facet Parsa, Roham
Lund, Harald
Georgoudaki, Anna-Maria
Zhang, Xing-Mei
Ortlieb Guerreiro-Cacais, André
Grommisch, David
Warnecke, Andreas
Croxford, Andrew L.
Jagodic, Maja
Becher, Burkhard
Karlsson, Mikael C.I.
Harris, Robert A.
author_sort Parsa, Roham
collection PubMed
description Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied immune activation after adjuvant administration. The initial neutropenic state fostered an environment of increased dendritic cell activation and T cell–derived IL-17 production. Interestingly, neutropenic lysozyme 2–diphtheria toxin A mice exhibited striking EG and amplified neutrophil recruitment to the lymph nodes (LNs) that was dependent on IL-17–induced prostaglandin activity. The recruited neutrophils secreted a B cell–activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. Reduction of neutrophil functions via granulocyte colony-stimulating factor neutralization significantly diminished plasma cell formation, directly linking EG with the humoral immune response. We conclude that neutrophils are capable of directly regulating T cell–dependent B cell responses in the LN.
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spelling pubmed-49865212017-01-25 BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis Parsa, Roham Lund, Harald Georgoudaki, Anna-Maria Zhang, Xing-Mei Ortlieb Guerreiro-Cacais, André Grommisch, David Warnecke, Andreas Croxford, Andrew L. Jagodic, Maja Becher, Burkhard Karlsson, Mikael C.I. Harris, Robert A. J Exp Med Research Articles Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied immune activation after adjuvant administration. The initial neutropenic state fostered an environment of increased dendritic cell activation and T cell–derived IL-17 production. Interestingly, neutropenic lysozyme 2–diphtheria toxin A mice exhibited striking EG and amplified neutrophil recruitment to the lymph nodes (LNs) that was dependent on IL-17–induced prostaglandin activity. The recruited neutrophils secreted a B cell–activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. Reduction of neutrophil functions via granulocyte colony-stimulating factor neutralization significantly diminished plasma cell formation, directly linking EG with the humoral immune response. We conclude that neutrophils are capable of directly regulating T cell–dependent B cell responses in the LN. The Rockefeller University Press 2016-07-25 /pmc/articles/PMC4986521/ /pubmed/27432941 http://dx.doi.org/10.1084/jem.20150577 Text en © 2016 Parsa et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Research Articles
Parsa, Roham
Lund, Harald
Georgoudaki, Anna-Maria
Zhang, Xing-Mei
Ortlieb Guerreiro-Cacais, André
Grommisch, David
Warnecke, Andreas
Croxford, Andrew L.
Jagodic, Maja
Becher, Burkhard
Karlsson, Mikael C.I.
Harris, Robert A.
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title_full BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title_fullStr BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title_full_unstemmed BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title_short BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
title_sort baff-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986521/
https://www.ncbi.nlm.nih.gov/pubmed/27432941
http://dx.doi.org/10.1084/jem.20150577
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