Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets

Naive CD4(+) T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human...

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Autores principales: Ma, Cindy S., Wong, Natalie, Rao, Geetha, Nguyen, Akira, Avery, Danielle T., Payne, Kathryn, Torpy, James, O’Young, Patrick, Deenick, Elissa, Bustamante, Jacinta, Puel, Anne, Okada, Satoshi, Kobayashi, Masao, Martinez-Barricarte, Ruben, Elliott, Michael, Sebnem Kilic, Sara, El Baghdadi, Jamila, Minegishi, Yoshiyuki, Bousfiha, Aziz, Robertson, Nic, Hambleton, Sophie, Arkwright, Peter D., French, Martyn, Blincoe, Annaliesse K., Hsu, Peter, Campbell, Dianne E., Stormon, Michael O., Wong, Melanie, Adelstein, Stephen, Fulcher, David A., Cook, Matthew C., Stepensky, Polina, Boztug, Kaan, Beier, Rita, Ikincioğullari, Aydan, Ziegler, John B., Gray, Paul, Picard, Capucine, Boisson-Dupuis, Stéphanie, Phan, Tri Giang, Grimbacher, Bodo, Warnatz, Klaus, Holland, Steven M., Uzel, Gulbu, Casanova, Jean-Laurent, Tangye, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986526/
https://www.ncbi.nlm.nih.gov/pubmed/27401342
http://dx.doi.org/10.1084/jem.20151467

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