Genetically distinct leukemic stem cells in human CD34(−) acute myeloid leukemia are arrested at a hemopoietic precursor-like stage

Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-lik...

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Detalles Bibliográficos
Autores principales: Quek, Lynn, Otto, Georg W., Garnett, Catherine, Lhermitte, Ludovic, Karamitros, Dimitris, Stoilova, Bilyana, Lau, I-Jun, Doondeea, Jessica, Usukhbayar, Batchimeg, Kennedy, Alison, Metzner, Marlen, Goardon, Nicolas, Ivey, Adam, Allen, Christopher, Gale, Rosemary, Davies, Benjamin, Sternberg, Alexander, Killick, Sally, Hunter, Hannah, Cahalin, Paul, Price, Andrew, Carr, Andrew, Griffiths, Mike, Virgo, Paul, Mackinnon, Stephen, Grimwade, David, Freeman, Sylvie, Russell, Nigel, Craddock, Charles, Mead, Adam, Peniket, Andrew, Porcher, Catherine, Vyas, Paresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986529/
https://www.ncbi.nlm.nih.gov/pubmed/27377587
http://dx.doi.org/10.1084/jem.20151775

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