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Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

Individuals with type 2 diabetes have an increased risk for developing Alzheimer’s disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain. Moreover, oligomers/fibrils of amyloid-β (Aβ) can lead to neuronal insulin...

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Detalles Bibliográficos
Autores principales: Stanley, Molly, Macauley, Shannon L., Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986537/
https://www.ncbi.nlm.nih.gov/pubmed/27432942
http://dx.doi.org/10.1084/jem.20160493