Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults

Sleep enhances motor sequence learning (MSL) in young adults by concatenating subsequences (“chunks”) formed during skill acquisition. To examine whether this process is reduced in aging, we assessed performance changes on the MSL task following overnight sleep or daytime wake in healthy young and o...

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Detalles Bibliográficos
Autores principales: Bottary, Ryan, Sonni, Akshata, Wright, David, Spencer, Rebecca M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986853/
https://www.ncbi.nlm.nih.gov/pubmed/27531835
http://dx.doi.org/10.1101/lm.043042.116
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author Bottary, Ryan
Sonni, Akshata
Wright, David
Spencer, Rebecca M. C.
author_facet Bottary, Ryan
Sonni, Akshata
Wright, David
Spencer, Rebecca M. C.
author_sort Bottary, Ryan
collection PubMed
description Sleep enhances motor sequence learning (MSL) in young adults by concatenating subsequences (“chunks”) formed during skill acquisition. To examine whether this process is reduced in aging, we assessed performance changes on the MSL task following overnight sleep or daytime wake in healthy young and older adults. Young adult performance enhancement was correlated with nREM2 sleep, and facilitated by preferential improvement of slowest within-sequence transitions. This effect was markedly reduced in older adults, and accompanied by diminished sigma power density (12–15 Hz) during nREM2 sleep, suggesting that diminished chunk concatenation following sleep may underlie reduced consolidation of MSL in older adults.
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spelling pubmed-49868532017-09-01 Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults Bottary, Ryan Sonni, Akshata Wright, David Spencer, Rebecca M. C. Learn Mem Brief Communication Sleep enhances motor sequence learning (MSL) in young adults by concatenating subsequences (“chunks”) formed during skill acquisition. To examine whether this process is reduced in aging, we assessed performance changes on the MSL task following overnight sleep or daytime wake in healthy young and older adults. Young adult performance enhancement was correlated with nREM2 sleep, and facilitated by preferential improvement of slowest within-sequence transitions. This effect was markedly reduced in older adults, and accompanied by diminished sigma power density (12–15 Hz) during nREM2 sleep, suggesting that diminished chunk concatenation following sleep may underlie reduced consolidation of MSL in older adults. Cold Spring Harbor Laboratory Press 2016-09 /pmc/articles/PMC4986853/ /pubmed/27531835 http://dx.doi.org/10.1101/lm.043042.116 Text en © 2016 Bottary et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Bottary, Ryan
Sonni, Akshata
Wright, David
Spencer, Rebecca M. C.
Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title_full Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title_fullStr Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title_full_unstemmed Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title_short Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
title_sort insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986853/
https://www.ncbi.nlm.nih.gov/pubmed/27531835
http://dx.doi.org/10.1101/lm.043042.116
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