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Increased task demand during spatial memory testing recruits the anterior cingulate cortex

We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested...

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Detalles Bibliográficos
Autores principales: Carr, Joshua K., Fournier, Neil M., Lehmann, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986854/
https://www.ncbi.nlm.nih.gov/pubmed/27531834
http://dx.doi.org/10.1101/lm.042366.116
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author Carr, Joshua K.
Fournier, Neil M.
Lehmann, Hugo
author_facet Carr, Joshua K.
Fournier, Neil M.
Lehmann, Hugo
author_sort Carr, Joshua K.
collection PubMed
description We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested three or 30 d later. Retrieval difficulty was manipulated by removing several prominent extra-pool cues from the testing room. Immediate early gene expression (c-Fos) in the ACC was greater following the cue removal and comparable to remote memory retrieval (30-d retention interval) levels, supporting the view of increased ACC contribution during high cognitive-demand memory processes.
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spelling pubmed-49868542017-09-01 Increased task demand during spatial memory testing recruits the anterior cingulate cortex Carr, Joshua K. Fournier, Neil M. Lehmann, Hugo Learn Mem Brief Communication We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested three or 30 d later. Retrieval difficulty was manipulated by removing several prominent extra-pool cues from the testing room. Immediate early gene expression (c-Fos) in the ACC was greater following the cue removal and comparable to remote memory retrieval (30-d retention interval) levels, supporting the view of increased ACC contribution during high cognitive-demand memory processes. Cold Spring Harbor Laboratory Press 2016-09 /pmc/articles/PMC4986854/ /pubmed/27531834 http://dx.doi.org/10.1101/lm.042366.116 Text en © 2016 Carr et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Carr, Joshua K.
Fournier, Neil M.
Lehmann, Hugo
Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title_full Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title_fullStr Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title_full_unstemmed Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title_short Increased task demand during spatial memory testing recruits the anterior cingulate cortex
title_sort increased task demand during spatial memory testing recruits the anterior cingulate cortex
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986854/
https://www.ncbi.nlm.nih.gov/pubmed/27531834
http://dx.doi.org/10.1101/lm.042366.116
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