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Increased task demand during spatial memory testing recruits the anterior cingulate cortex
We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986854/ https://www.ncbi.nlm.nih.gov/pubmed/27531834 http://dx.doi.org/10.1101/lm.042366.116 |
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author | Carr, Joshua K. Fournier, Neil M. Lehmann, Hugo |
author_facet | Carr, Joshua K. Fournier, Neil M. Lehmann, Hugo |
author_sort | Carr, Joshua K. |
collection | PubMed |
description | We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested three or 30 d later. Retrieval difficulty was manipulated by removing several prominent extra-pool cues from the testing room. Immediate early gene expression (c-Fos) in the ACC was greater following the cue removal and comparable to remote memory retrieval (30-d retention interval) levels, supporting the view of increased ACC contribution during high cognitive-demand memory processes. |
format | Online Article Text |
id | pubmed-4986854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49868542017-09-01 Increased task demand during spatial memory testing recruits the anterior cingulate cortex Carr, Joshua K. Fournier, Neil M. Lehmann, Hugo Learn Mem Brief Communication We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested three or 30 d later. Retrieval difficulty was manipulated by removing several prominent extra-pool cues from the testing room. Immediate early gene expression (c-Fos) in the ACC was greater following the cue removal and comparable to remote memory retrieval (30-d retention interval) levels, supporting the view of increased ACC contribution during high cognitive-demand memory processes. Cold Spring Harbor Laboratory Press 2016-09 /pmc/articles/PMC4986854/ /pubmed/27531834 http://dx.doi.org/10.1101/lm.042366.116 Text en © 2016 Carr et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Brief Communication Carr, Joshua K. Fournier, Neil M. Lehmann, Hugo Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title | Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title_full | Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title_fullStr | Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title_full_unstemmed | Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title_short | Increased task demand during spatial memory testing recruits the anterior cingulate cortex |
title_sort | increased task demand during spatial memory testing recruits the anterior cingulate cortex |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986854/ https://www.ncbi.nlm.nih.gov/pubmed/27531834 http://dx.doi.org/10.1101/lm.042366.116 |
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