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An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex

It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we explored whether an unrelated appetitive experience (voluntary consumption of...

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Detalles Bibliográficos
Autores principales: Ferrer Monti, Roque I., Giachero, Marcelo, Alfei, Joaquín M., Bueno, Adrián M., Cuadra, Gabriel, Molina, Victor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986855/
https://www.ncbi.nlm.nih.gov/pubmed/27531837
http://dx.doi.org/10.1101/lm.042564.116
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author Ferrer Monti, Roque I.
Giachero, Marcelo
Alfei, Joaquín M.
Bueno, Adrián M.
Cuadra, Gabriel
Molina, Victor A.
author_facet Ferrer Monti, Roque I.
Giachero, Marcelo
Alfei, Joaquín M.
Bueno, Adrián M.
Cuadra, Gabriel
Molina, Victor A.
author_sort Ferrer Monti, Roque I.
collection PubMed
description It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we explored whether an unrelated appetitive experience (voluntary consumption of diluted sucrose) can affect a contextual fear memory in rats during the reactivation-induced destabilization phase. Our findings show that exposure to an appetitive experience following reactivation can diminish fear retention. This effect persisted after 1 wk. Importantly, it was achieved only under conditions that induced fear memory destabilization. This result could not be explained as a potentiated extinction, because sucrose was unable to promote extinction. Since GluN2B-containing NMDA receptors in the basolateral amygdala complex (BLA) have been implicated in triggering fear memory destabilization, we decided to block pharmacologically these receptors to explore the neurobiological bases of the observed effect. Intra-BLA infusion with ifenprodil, a GluN2B-NMDA antagonist, prevented the fear reduction caused by the appetitive experience. In sum, these results suggest that the expression of a fear memory can be dampened by an unrelated appetitive experience, as long as memory destabilization is achieved during reactivation. Possible mechanisms behind this effect and its clinical implications are discussed.
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spelling pubmed-49868552017-09-01 An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex Ferrer Monti, Roque I. Giachero, Marcelo Alfei, Joaquín M. Bueno, Adrián M. Cuadra, Gabriel Molina, Victor A. Learn Mem Research It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we explored whether an unrelated appetitive experience (voluntary consumption of diluted sucrose) can affect a contextual fear memory in rats during the reactivation-induced destabilization phase. Our findings show that exposure to an appetitive experience following reactivation can diminish fear retention. This effect persisted after 1 wk. Importantly, it was achieved only under conditions that induced fear memory destabilization. This result could not be explained as a potentiated extinction, because sucrose was unable to promote extinction. Since GluN2B-containing NMDA receptors in the basolateral amygdala complex (BLA) have been implicated in triggering fear memory destabilization, we decided to block pharmacologically these receptors to explore the neurobiological bases of the observed effect. Intra-BLA infusion with ifenprodil, a GluN2B-NMDA antagonist, prevented the fear reduction caused by the appetitive experience. In sum, these results suggest that the expression of a fear memory can be dampened by an unrelated appetitive experience, as long as memory destabilization is achieved during reactivation. Possible mechanisms behind this effect and its clinical implications are discussed. Cold Spring Harbor Laboratory Press 2016-09 /pmc/articles/PMC4986855/ /pubmed/27531837 http://dx.doi.org/10.1101/lm.042564.116 Text en © 2016 Ferrer Monti et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Ferrer Monti, Roque I.
Giachero, Marcelo
Alfei, Joaquín M.
Bueno, Adrián M.
Cuadra, Gabriel
Molina, Victor A.
An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title_full An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title_fullStr An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title_full_unstemmed An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title_short An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex
title_sort appetitive experience after fear memory destabilization attenuates fear retention: involvement glun2b-nmda receptors in the basolateral amygdala complex
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986855/
https://www.ncbi.nlm.nih.gov/pubmed/27531837
http://dx.doi.org/10.1101/lm.042564.116
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