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ATPγS stalls splicing after B complex formation but prior to spliceosome activation

The ATP analog ATPγS inhibits pre-mRNA splicing in vitro, but there have been conflicting reports as to which step of splicing is inhibited by this small molecule and its inhibitory mechanism remains unclear. Here we have dissected the effect of ATPγS on pre-mRNA splicing in vitro. Addition of ATPγS...

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Detalles Bibliográficos
Autores principales:	Agafonov, Dmitry E., van Santen, Marieke, Kastner, Berthold, Dube, Prakash, Will, Cindy L., Urlaub, Henning, Lührmann, Reinhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986889/ https://www.ncbi.nlm.nih.gov/pubmed/27411562 http://dx.doi.org/10.1261/rna.057810.116

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