Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to promote their targeting by cytotoxic T-lymphocytes (CTL). However, HDACi may also inhibit CTL function, suggesting different immunotherapy app...

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Detalles Bibliográficos
Autores principales: Pace, Matthew, Williams, James, Kurioka, Ayako, Gerry, Andrew B., Jakobsen, Bent, Klenerman, Paul, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Frater, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986965/
https://www.ncbi.nlm.nih.gov/pubmed/27529554
http://dx.doi.org/10.1371/journal.ppat.1005782

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