Enhanced Pulmonary Vascular and Alveolar Development via Prenatal Administration of a Slow-Release Synthetic Prostacyclin Agonist in Rat Fetal Lung Hypoplasia

Lung hypoplasia and pulmonary hypertension are the major causes of mortality in neonates with congenital diaphragmatic hernia (CDH). Although the prostaglandin pathway plays a pivotal role in lung development, the reported efficacy of postnatal prostaglandin agonist treatment is suboptimal. We hypot...

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Detalles Bibliográficos
Autores principales: Umeda, Satoshi, Miyagawa, Shigeru, Fukushima, Satsuki, Oda, Noriko, Saito, Atsuhiro, Sakai, Yoshiki, Sawa, Yoshiki, Okuyama, Hiroomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987057/
https://www.ncbi.nlm.nih.gov/pubmed/27529478
http://dx.doi.org/10.1371/journal.pone.0161334

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