Evolution of the Calcium-Based Intracellular Signaling System

To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain p...

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Autores principales: Marchadier, Elodie, Oates, Matt E., Fang, Hai, Donoghue, Philip C.J., Hetherington, Alistair M., Gough, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987107/
https://www.ncbi.nlm.nih.gov/pubmed/27358427
http://dx.doi.org/10.1093/gbe/evw139
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author Marchadier, Elodie
Oates, Matt E.
Fang, Hai
Donoghue, Philip C.J.
Hetherington, Alistair M.
Gough, Julian
author_facet Marchadier, Elodie
Oates, Matt E.
Fang, Hai
Donoghue, Philip C.J.
Hetherington, Alistair M.
Gough, Julian
author_sort Marchadier, Elodie
collection PubMed
description To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals.
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spelling pubmed-49871072016-08-22 Evolution of the Calcium-Based Intracellular Signaling System Marchadier, Elodie Oates, Matt E. Fang, Hai Donoghue, Philip C.J. Hetherington, Alistair M. Gough, Julian Genome Biol Evol Research Article To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals. Oxford University Press 2016-06-29 /pmc/articles/PMC4987107/ /pubmed/27358427 http://dx.doi.org/10.1093/gbe/evw139 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Marchadier, Elodie
Oates, Matt E.
Fang, Hai
Donoghue, Philip C.J.
Hetherington, Alistair M.
Gough, Julian
Evolution of the Calcium-Based Intracellular Signaling System
title Evolution of the Calcium-Based Intracellular Signaling System
title_full Evolution of the Calcium-Based Intracellular Signaling System
title_fullStr Evolution of the Calcium-Based Intracellular Signaling System
title_full_unstemmed Evolution of the Calcium-Based Intracellular Signaling System
title_short Evolution of the Calcium-Based Intracellular Signaling System
title_sort evolution of the calcium-based intracellular signaling system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987107/
https://www.ncbi.nlm.nih.gov/pubmed/27358427
http://dx.doi.org/10.1093/gbe/evw139
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