Evolution of the Calcium-Based Intracellular Signaling System
To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987107/ https://www.ncbi.nlm.nih.gov/pubmed/27358427 http://dx.doi.org/10.1093/gbe/evw139 |
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author | Marchadier, Elodie Oates, Matt E. Fang, Hai Donoghue, Philip C.J. Hetherington, Alistair M. Gough, Julian |
author_facet | Marchadier, Elodie Oates, Matt E. Fang, Hai Donoghue, Philip C.J. Hetherington, Alistair M. Gough, Julian |
author_sort | Marchadier, Elodie |
collection | PubMed |
description | To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals. |
format | Online Article Text |
id | pubmed-4987107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49871072016-08-22 Evolution of the Calcium-Based Intracellular Signaling System Marchadier, Elodie Oates, Matt E. Fang, Hai Donoghue, Philip C.J. Hetherington, Alistair M. Gough, Julian Genome Biol Evol Research Article To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals. Oxford University Press 2016-06-29 /pmc/articles/PMC4987107/ /pubmed/27358427 http://dx.doi.org/10.1093/gbe/evw139 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Marchadier, Elodie Oates, Matt E. Fang, Hai Donoghue, Philip C.J. Hetherington, Alistair M. Gough, Julian Evolution of the Calcium-Based Intracellular Signaling System |
title | Evolution of the Calcium-Based Intracellular Signaling System |
title_full | Evolution of the Calcium-Based Intracellular Signaling System |
title_fullStr | Evolution of the Calcium-Based Intracellular Signaling System |
title_full_unstemmed | Evolution of the Calcium-Based Intracellular Signaling System |
title_short | Evolution of the Calcium-Based Intracellular Signaling System |
title_sort | evolution of the calcium-based intracellular signaling system |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987107/ https://www.ncbi.nlm.nih.gov/pubmed/27358427 http://dx.doi.org/10.1093/gbe/evw139 |
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