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Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome inhibitor drugs. In Caenorhabditis elegans, this response requires SKN-1...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987142/ https://www.ncbi.nlm.nih.gov/pubmed/27528192 http://dx.doi.org/10.7554/eLife.17721 |