DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes

Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages...

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Autores principales: Cruz-Reyes, Jorge, Mooers, Blaine H.M., Abu-Adas, Zakaria, Kumar, Vikas, Gulati, Shelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987287/
https://www.ncbi.nlm.nih.gov/pubmed/27540585
http://dx.doi.org/10.14800/rd.1336
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author Cruz-Reyes, Jorge
Mooers, Blaine H.M.
Abu-Adas, Zakaria
Kumar, Vikas
Gulati, Shelly
author_facet Cruz-Reyes, Jorge
Mooers, Blaine H.M.
Abu-Adas, Zakaria
Kumar, Vikas
Gulati, Shelly
author_sort Cruz-Reyes, Jorge
collection PubMed
description Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100–400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.
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spelling pubmed-49872872016-08-16 DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes Cruz-Reyes, Jorge Mooers, Blaine H.M. Abu-Adas, Zakaria Kumar, Vikas Gulati, Shelly RNA Dis Article Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100–400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans. 2016-06-06 2016 /pmc/articles/PMC4987287/ /pubmed/27540585 http://dx.doi.org/10.14800/rd.1336 Text en http://creativecommons.org/licenses/by/4.0/ Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.
spellingShingle Article
Cruz-Reyes, Jorge
Mooers, Blaine H.M.
Abu-Adas, Zakaria
Kumar, Vikas
Gulati, Shelly
DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title_full DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title_fullStr DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title_full_unstemmed DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title_short DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes
title_sort deah-rha helicase•znf cofactor systems in kinetoplastid rna editing and evolutionarily distant rna processes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987287/
https://www.ncbi.nlm.nih.gov/pubmed/27540585
http://dx.doi.org/10.14800/rd.1336
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