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A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

Tim17 is a central, membrane-embedded subunit of the mitochondrial protein import machinery. In this study, we show that Tim17 contains a pair of highly conserved cysteine residues that form a structural disulfide bond exposed to the intermembrane space (IMS). This disulfide bond is critical for eff...

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Detalles Bibliográficos
Autores principales:	Ramesh, Ajay, Peleh, Valentina, Martinez-Caballero, Sonia, Wollweber, Florian, Sommer, Frederik, van der Laan, Martin, Schroda, Michael, Alexander, R. Todd, Campo, María Luisa, Herrmann, Johannes M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987294/ https://www.ncbi.nlm.nih.gov/pubmed/27502485 http://dx.doi.org/10.1083/jcb.201602074

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