Cargando…

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking

Ras guanosine triphosphatases (GTPases) regulate signaling pathways only when associated with cellular membranes through their C-terminal prenylated regions. Ras proteins move between membrane compartments in part via diffusion-limited, fluid phase transfer through the cytosol, suggesting that chape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Mo, Wiener, Heidi, Su, Wenjuan, Zhou, Yong, Liot, Caroline, Ahearn, Ian, Hancock, John F., Philips, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987297/ https://www.ncbi.nlm.nih.gov/pubmed/27502489 http://dx.doi.org/10.1083/jcb.201604061

Ejemplares similares

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane
por: Ahearn, Ian M, et al.
Publicado: (2021)

Lipid Profiles of RAS Nanoclusters Regulate RAS Function
por: Zhou, Yong, et al.
Publicado: (2021)

Reversal of the Ras-Induced Transformed Phenotype by Hr12, a Novel Ras Farnesylation Inhibitor, Is Mediated by the Mek/ERK Pathway
por: Reuveni, Hadas, et al.
Publicado: (2000)

Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.
por: Nagase, T., et al.
Publicado: (1997)

Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells
por: Meinohl, Christopher, et al.
Publicado: (2019)

Comparison of K-Ras and N-Ras Mutagenic Hot Spots for UVC Damage
por: Nair, Sindhu G., et al.
Publicado: (2019)

Compartmentalized Ras signaling in lymphocytes
por: Philips, MR
Publicado: (2009)

Molecular Analysis of Oncogenes, ras Family Genes (N‐ras, K‐ras, H‐ras), myc Family Genes (c‐myc, N‐myc) and mdm2 in Natural Killer Cell Neoplasms
por: Sugimoto, Kei‐ji, et al.
Publicado: (2002)

The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis
por: Zhu, Ruilou, et al.
Publicado: (2019)

Altered expression of Bcl-2, c-Myc, H-Ras, K-Ras, and N-Ras does not influence the course of mycosis fungoides
por: Maj, Joanna, et al.
Publicado: (2013)

Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
por: Ferguson, Robert, et al.
Publicado: (2023)

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
por: Zheng, Kang, et al.
Publicado: (2023)

Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin
por: Wu, Ling-Jia, et al.
Publicado: (2011)

Mutational Activation of H‐ras and K‐ras Genes Is Absent in N‐Nitroso‐N‐methylurea‐induced Liver Tumors in Rats
por: Sakai, Hirotsuka, et al.
Publicado: (1990)

RAS variant signalling
por: Mo, Stephanie P., et al.
Publicado: (2018)

RAS GTPases are modified by SUMOylation
por: Choi, Byeong Hyeok, et al.
Publicado: (2017)

Parkinson’s Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread
por: Ding, Yingzhuo, et al.
Publicado: (2021)

PGA(1)-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes
por: Anta, B, et al.
Publicado: (2016)

Low Incidence of Point Mutation of c‐Ki‐ras and N‐ras Oncogenes in Human Hepatocellular Carcinoma
por: Tsuda, Hitoshi, et al.
Publicado: (1989)

Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
por: Shin, Seung-Min, et al.
Publicado: (2020)

CHMP6 and VPS4A mediate recycling of Ras to the plasma membrane to promote growth factor signaling
por: Zheng, Ze-Yi, et al.
Publicado: (2012)

MEK targeting in N-RAS mutated metastatic melanoma
por: Thumar, Jaykumar, et al.
Publicado: (2014)

Induction of N-Ras degradation by flunarizine-mediated autophagy
por: Zheng, Ze-Yi, et al.
Publicado: (2018)

Activated N-Ras signaling regulates arterial-venous specification in zebrafish
por: Ren, Chun-Guang, et al.
Publicado: (2013)

Origin and Evolution of RAS Oncoprotein Membrane Targeting
por: García-España, Antonio, et al.
Publicado: (2023)

Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras
por: Saikia, Minakshi, et al.
Publicado: (2018)

Dynamic regulation of RAS and RAS signaling
por: Kolch, Walter, et al.
Publicado: (2023)

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
por: Tian, Yun, et al.
Publicado: (2015)

Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy
por: Liu, Wei, et al.
Publicado: (2017)

Specific contributions of H-Ras and N-Ras GTPases to T-lymphocyte oxidative stress and integrin-dependent retention in rheumatoid arthritis
por: Remans, PHJ, et al.
Publicado: (2005)

One-way membrane trafficking of SOS in receptor-triggered Ras activation
por: Christensen, Sune M., et al.
Publicado: (2016)

Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies
por: Yu, Fang, et al.
Publicado: (2023)

Ras protein abundance correlates with Ras isoform mutation patterns in cancer
por: Hood, Fiona E., et al.
Publicado: (2023)

VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1
por: Wang, Chun-Lei, et al.
Publicado: (2012)

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient‐Derived Neurons
por: Hanss, Zoé, et al.
Publicado: (2020)

VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
por: Niu, Mengyue, et al.
Publicado: (2021)

Ras Farnesylation Inhibitor FTI‐277 Restores the E‐Cadherin/Catenin Cell Adhesion System in Human Cancer Cells and Reduces Cancer Metastasis
por: Nam, Jeong‐Seok, et al.
Publicado: (2002)

Sequence‐Selective Covalent CaaX‐Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling
por: Franz, Matthias, et al.
Publicado: (2021)

Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle
por: Castellano, Esther, et al.
Publicado: (2009)

Sorting of Yeast Membrane Proteins into an Endosome-to-Golgi Pathway Involves Direct Interaction of Their Cytosolic Domains with Vps35p
por: Nothwehr, Steven F., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_krc2npplvhods9jl44ohce57dl