Mitochondrial protein import: An unexpected disulfide bond

Most mitochondrial proteins are imported through the TIM23 translocation channel, the structure and molecular nature of which are still unclear. In this issue, Ramesh et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602074) show that the TIM23 subunit Tim17 contains a disulfide bond that...

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Detalles Bibliográficos
Autor principal: Mokranjac, Dejana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987298/
https://www.ncbi.nlm.nih.gov/pubmed/27502488
http://dx.doi.org/10.1083/jcb.201607117
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author Mokranjac, Dejana
author_facet Mokranjac, Dejana
author_sort Mokranjac, Dejana
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description Most mitochondrial proteins are imported through the TIM23 translocation channel, the structure and molecular nature of which are still unclear. In this issue, Ramesh et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602074) show that the TIM23 subunit Tim17 contains a disulfide bond that is crucial for protein translocation and channel gating.
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spelling pubmed-49872982017-02-15 Mitochondrial protein import: An unexpected disulfide bond Mokranjac, Dejana J Cell Biol Commentary Most mitochondrial proteins are imported through the TIM23 translocation channel, the structure and molecular nature of which are still unclear. In this issue, Ramesh et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602074) show that the TIM23 subunit Tim17 contains a disulfide bond that is crucial for protein translocation and channel gating. The Rockefeller University Press 2016-08-15 /pmc/articles/PMC4987298/ /pubmed/27502488 http://dx.doi.org/10.1083/jcb.201607117 Text en © 2016 Mokranjac This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Mokranjac, Dejana
Mitochondrial protein import: An unexpected disulfide bond
title Mitochondrial protein import: An unexpected disulfide bond
title_full Mitochondrial protein import: An unexpected disulfide bond
title_fullStr Mitochondrial protein import: An unexpected disulfide bond
title_full_unstemmed Mitochondrial protein import: An unexpected disulfide bond
title_short Mitochondrial protein import: An unexpected disulfide bond
title_sort mitochondrial protein import: an unexpected disulfide bond
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987298/
https://www.ncbi.nlm.nih.gov/pubmed/27502488
http://dx.doi.org/10.1083/jcb.201607117
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