Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network

Recent studies reveal a conserved role for FoxO transcription factors in establishing neuronal structure and circuit function. In this issue, McLaughlin et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601014) identify a novel Toll-like receptor–FoxO pathway that represses the mitotic ki...

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Autor principal: O’Connor-Giles, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987299/
https://www.ncbi.nlm.nih.gov/pubmed/27528655
http://dx.doi.org/10.1083/jcb.201607118
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author O’Connor-Giles, Kate
author_facet O’Connor-Giles, Kate
author_sort O’Connor-Giles, Kate
collection PubMed
description Recent studies reveal a conserved role for FoxO transcription factors in establishing neuronal structure and circuit function. In this issue, McLaughlin et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601014) identify a novel Toll-like receptor–FoxO pathway that represses the mitotic kinesin Pavarotti/MKLP1 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of presynaptic terminals.
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spelling pubmed-49872992017-02-15 Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network O’Connor-Giles, Kate J Cell Biol Commentary Recent studies reveal a conserved role for FoxO transcription factors in establishing neuronal structure and circuit function. In this issue, McLaughlin et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601014) identify a novel Toll-like receptor–FoxO pathway that represses the mitotic kinesin Pavarotti/MKLP1 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of presynaptic terminals. The Rockefeller University Press 2016-08-15 /pmc/articles/PMC4987299/ /pubmed/27528655 http://dx.doi.org/10.1083/jcb.201607118 Text en © 2016 O'Connor-Giles This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
O’Connor-Giles, Kate
Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title_full Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title_fullStr Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title_full_unstemmed Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title_short Toll-tally tubular: A newly identified Toll-like receptor–FoxO pathway regulates dynamics of the neuronal microtubule network
title_sort toll-tally tubular: a newly identified toll-like receptor–foxo pathway regulates dynamics of the neuronal microtubule network
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987299/
https://www.ncbi.nlm.nih.gov/pubmed/27528655
http://dx.doi.org/10.1083/jcb.201607118
work_keys_str_mv AT oconnorgileskate tolltallytubularanewlyidentifiedtolllikereceptorfoxopathwayregulatesdynamicsoftheneuronalmicrotubulenetwork

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