ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play

Endoplasmic reticulum (ER)–mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER–mitochondria contact sites, thereby affectin...

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Detalles Bibliográficos
Autores principales: Krols, Michiel, Bultynck, Geert, Janssens, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987300/
https://www.ncbi.nlm.nih.gov/pubmed/27528654
http://dx.doi.org/10.1083/jcb.201607124
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author Krols, Michiel
Bultynck, Geert
Janssens, Sophie
author_facet Krols, Michiel
Bultynck, Geert
Janssens, Sophie
author_sort Krols, Michiel
collection PubMed
description Endoplasmic reticulum (ER)–mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER–mitochondria contact sites, thereby affecting ER–mitochondrial calcium transfer and mitochondrial bioenergetics.
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spelling pubmed-49873002017-02-15 ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play Krols, Michiel Bultynck, Geert Janssens, Sophie J Cell Biol Commentary Endoplasmic reticulum (ER)–mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER–mitochondria contact sites, thereby affecting ER–mitochondrial calcium transfer and mitochondrial bioenergetics. The Rockefeller University Press 2016-08-15 /pmc/articles/PMC4987300/ /pubmed/27528654 http://dx.doi.org/10.1083/jcb.201607124 Text en © 2016 Krols et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Krols, Michiel
Bultynck, Geert
Janssens, Sophie
ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title_full ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title_fullStr ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title_full_unstemmed ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title_short ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
title_sort er–mitochondria contact sites: a new regulator of cellular calcium flux comes into play
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987300/
https://www.ncbi.nlm.nih.gov/pubmed/27528654
http://dx.doi.org/10.1083/jcb.201607124
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