Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay

Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract...

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Detalles Bibliográficos
Autores principales: Durand, Sébastien, Franks, Tobias M., Lykke-Andersen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987530/
https://www.ncbi.nlm.nih.gov/pubmed/27511142
http://dx.doi.org/10.1038/ncomms12434

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