Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that severa...

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Detalles Bibliográficos
Autores principales: Daniels, Michael J. D., Rivers-Auty, Jack, Schilling, Tom, Spencer, Nicholas G., Watremez, William, Fasolino, Victoria, Booth, Sophie J., White, Claire S., Baldwin, Alex G., Freeman, Sally, Wong, Raymond, Latta, Clare, Yu, Shi, Jackson, Joshua, Fischer, Nicolas, Koziel, Violette, Pillot, Thierry, Bagnall, James, Allan, Stuart M., Paszek, Pawel, Galea, James, Harte, Michael K., Eder, Claudia, Lawrence, Catherine B., Brough, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987536/
https://www.ncbi.nlm.nih.gov/pubmed/27509875
http://dx.doi.org/10.1038/ncomms12504

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