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ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat
Premature birth in conjunction with extremely low birth weight (<1 kg, ELBW) is associated with insulin resistance and increased cardiometabolic health risk compared to birth at full term with normal birth weight (NBW). However, little is known regarding the biologic mediators of these effects. A...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987614/ https://www.ncbi.nlm.nih.gov/pubmed/27530702 http://dx.doi.org/10.1038/srep31560 |
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author | Crane, Justin D. Yellin, Samuel A. Ong, Frank J. Singh, Nina P. Konyer, Norman Noseworthy, Michael D. Schmidt, Louis A. Saigal, Saroj Morrison, Katherine M. |
author_facet | Crane, Justin D. Yellin, Samuel A. Ong, Frank J. Singh, Nina P. Konyer, Norman Noseworthy, Michael D. Schmidt, Louis A. Saigal, Saroj Morrison, Katherine M. |
author_sort | Crane, Justin D. |
collection | PubMed |
description | Premature birth in conjunction with extremely low birth weight (<1 kg, ELBW) is associated with insulin resistance and increased cardiometabolic health risk compared to birth at full term with normal birth weight (NBW). However, little is known regarding the biologic mediators of these effects. Abdominal and ectopic lipid accumulation is linked to insulin resistance and metabolic dysfunction, yet whether ELBW survivors are predisposed to aberrant lipid deposition in adulthood is unknown. We used magnetic resonance imaging in a cohort of 16 NBW and 29 ELBW participants to determine if ELBW survivors have differences in pancreatic, hepatic, subcutaneous and visceral fat distribution compared to NBW participants. ELBW individuals had a higher proportion of liver and pancreatic fat compared to NBW subjects (P < 0.05). Abdominal subcutaneous fat, but not visceral fat, area was higher in ELBW survivors compared to NBW individuals. In multivariate analyses, tissue fat measures were most highly related to BMI and sex, but not preterm birth. This work highlights that fat deposition is enhanced in adults born preterm and suggests that ectopic fat accretion driven by their relatively greater adiposity may contribute to the higher rates of metabolic dysfunction seen in ELBW survivors. |
format | Online Article Text |
id | pubmed-4987614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49876142016-08-30 ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat Crane, Justin D. Yellin, Samuel A. Ong, Frank J. Singh, Nina P. Konyer, Norman Noseworthy, Michael D. Schmidt, Louis A. Saigal, Saroj Morrison, Katherine M. Sci Rep Article Premature birth in conjunction with extremely low birth weight (<1 kg, ELBW) is associated with insulin resistance and increased cardiometabolic health risk compared to birth at full term with normal birth weight (NBW). However, little is known regarding the biologic mediators of these effects. Abdominal and ectopic lipid accumulation is linked to insulin resistance and metabolic dysfunction, yet whether ELBW survivors are predisposed to aberrant lipid deposition in adulthood is unknown. We used magnetic resonance imaging in a cohort of 16 NBW and 29 ELBW participants to determine if ELBW survivors have differences in pancreatic, hepatic, subcutaneous and visceral fat distribution compared to NBW participants. ELBW individuals had a higher proportion of liver and pancreatic fat compared to NBW subjects (P < 0.05). Abdominal subcutaneous fat, but not visceral fat, area was higher in ELBW survivors compared to NBW individuals. In multivariate analyses, tissue fat measures were most highly related to BMI and sex, but not preterm birth. This work highlights that fat deposition is enhanced in adults born preterm and suggests that ectopic fat accretion driven by their relatively greater adiposity may contribute to the higher rates of metabolic dysfunction seen in ELBW survivors. Nature Publishing Group 2016-08-17 /pmc/articles/PMC4987614/ /pubmed/27530702 http://dx.doi.org/10.1038/srep31560 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Crane, Justin D. Yellin, Samuel A. Ong, Frank J. Singh, Nina P. Konyer, Norman Noseworthy, Michael D. Schmidt, Louis A. Saigal, Saroj Morrison, Katherine M. ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title | ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title_full | ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title_fullStr | ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title_full_unstemmed | ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title_short | ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
title_sort | elbw survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987614/ https://www.ncbi.nlm.nih.gov/pubmed/27530702 http://dx.doi.org/10.1038/srep31560 |
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