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Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the Erb...
Autores principales: | Kawasaki, Yuki, Sakimura, Ayaka, Park, Chul Min, Tomaru, Rika, Tanaka, Tomohiro, Ozawa, Tatsuhiko, Zhou, Yue, Narita, Kaori, Kishi, Hiroyuki, Muraguchi, Atsushi, Sakurai, Hiroaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987620/ https://www.ncbi.nlm.nih.gov/pubmed/27531070 http://dx.doi.org/10.1038/srep31502 |
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