In-depth phylogenetic analysis of hepatitis C virus subtype 1a and occurrence of 80K and associated polymorphisms in the NS3 protease

HCV genetic diversity is high and impacts disease progression, treatment and drug resistance. HCV subtype 1a is divided in two clades (I and II), and the 80 K natural polymorphism in the viral NS3 protease is prevalent in clade I. Paradoxically, countries dominated by this clade have contrasting fre...

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Detalles Bibliográficos
Autores principales: Santos, André F., Bello, Gonzalo, Vidal, Luãnna L., Souza, Suiane L., Mir, Daiana, Soares, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987637/
https://www.ncbi.nlm.nih.gov/pubmed/27531254
http://dx.doi.org/10.1038/srep31780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987637/
https://www.ncbi.nlm.nih.gov/pubmed/27531254
http://dx.doi.org/10.1038/srep31780

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