Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors

Systematic structural modifications of the muramic acid, peptide, and nucleotide moieties of Park’s nucleotide were performed to investigate the substrate specificity of B. subtilis MraY (MraY(BS)). It was found that the simplest analogue of Park’s nucleotide only bearing the first two amino acids,...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Kuo-Ting, Chen, Po-Ting, Lin, Cheng-Kun, Huang, Lin-Ya, Hu, Chia-Ming, Chang, Yi-Fan, Hsu, Hua-Ting, Cheng, Ting-Jen R., Wu, Ying-Ta, Cheng, Wei-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987650/
https://www.ncbi.nlm.nih.gov/pubmed/27531195
http://dx.doi.org/10.1038/srep31579

Ejemplares similares

Ejemplares similares